SCHEMBL23617296

SCHEMBL23617296

Bc1cc(CC(=O)OC)cc2ccoc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 1/20 0.46
ALDH1A1 P00352 4/20 0.43
GAA P10253 1/20 0.43
GFER P55789 1/20 0.43
CYP4F2 P78329 1/20 0.41
CYP4A11 Q02928 1/20 0.41
MAPK1 P28482 2/20 0.38
TSHR P16473 2/20 0.38
MAOA P21397 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2A6 P11509 1/20 0.38
ACHE P22303 1/20 0.38
PDE4A P27815 1/20 0.38
CYP2C19 P33261 1/20 0.38
SLC6A3 Q01959 1/20 0.38
CYP2A13 Q16696 1/20 0.38
KDM4E B2RXH2 4/20 0.38
MAPT P10636 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21437429 0.84 HSP90AB1 (0.45) HSP90AB1ALDH1A1GAAGFERCYP4F2
SCHEMBL23617163 0.76 KDM4E (0.32) ALDH1A1GAAMAPK1TSHRMAOA
SCHEMBL29875194 0.76 HTR1B (0.50) HSP90AB1ALDH1A1GAAGFERCYP4F2
SCHEMBL7442715 0.76 HTR1B (0.50) HSP90AB1ALDH1A1GAAGFERCYP4F2
SCHEMBL23616708 0.73 MAOA (0.32) MAPK1TSHRMAOACYP1A2CYP3A4
SCHEMBL5372809 0.72 TRPM8 (0.41) ALDH1A1GAAMAOAKDM4EMAPT
SCHEMBL21891794 0.71 HSP90AB1 (0.75) HSP90AB1ALDH1A1GAAGFERCYP4F2
SCHEMBL23217674 0.70 SMN1; SMN2 (0.39) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL14531746 0.70 GAA (0.61) HSP90AB1ALDH1A1GAAGFERCYP4F2
SCHEMBL21620954 0.70 ALDH1A1 (0.61) HSP90AB1ALDH1A1GAAGFERCYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3687506-B1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS BIOCRYST PHARM INC (US) 2021-07-07 EP disclosed