Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.58 |
| ▸ | MAOA | P21397 | 3/20 | 0.58 |
| ▸ | ESR1 | P03372 | 2/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23617312 | 0.86 | MAOA (0.52) | MAOBMAOAESR1ESR2HTT | |
| SCHEMBL21437469 | 0.82 | MAOA (0.43) | MAOBMAOAPTGER1ALDH1A1NPC1 | |
| SCHEMBL23617283 | 0.77 | TTR (0.44) | MAOAESR1TTRMEN1ALDH1A1 | |
| SCHEMBL23073036 | 0.76 | MAOB (0.63) | MAOBMAOAESR1ESR2ALDH1A1 | |
| SCHEMBL23617313 | 0.76 | MAOB (0.58) | MAOBMAOAESR1ESR2PTGER1 | |
| 2-Picolinic Acid SCHEMBL4566196 | 0.74 | PTGER1 (0.56) | MAOBMAOAESR1ESR2PTGER1 | |
| SCHEMBL16938476 | 0.74 | MAOB (0.59) | MAOBMAOAESR1ESR2MEN1 | |
| SCHEMBL14266214 | 0.74 | MAOB (0.59) | MAOBMAOAESR1ESR2MEN1 | |
| SCHEMBL14266211 | 0.74 | MAOB (0.59) | MAOBMAOAESR1ESR2MEN1 | |
| SCHEMBL11732417 | 0.74 | MAOB (1.00) | MAOBMAOAESR1ESR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3687506-B1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARM INC (US) | 2021-07-07 | — | — | EP | disclosed |