Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23620145 | 0.94 | LRRK2 (0.46) | LRRK2HCRTR1HCRTR2IRAK4 | |
| SCHEMBL24713380 | 0.83 | LRRK2 (0.41) | LRRK2HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL24713250 | 0.80 | LRRK2 (0.36) | LRRK2HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL24713323 | 0.78 | LRRK2 (0.35) | LRRK2HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL22041240 | 0.78 | PDE10A (0.39) | LRRK2HCRTR2HTR1AADRA2AADRA2B | |
| SCHEMBL23620095 | 0.78 | LRRK2 (0.49) | LRRK2IRAK4 | |
| SCHEMBL23620231 | 0.77 | CCNB2 (0.36) | LRRK2 | |
| SCHEMBL25144091 | 0.74 | LRRK2 (0.46) | LRRK2AXLTYRO3MERTK | |
| SCHEMBL25144094 | 0.74 | LRRK2 (0.43) | LRRK2HCRTR1HCRTR2IRAK4 | |
| SCHEMBL24713234 | 0.72 | TRPV4 (0.38) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021136238-A1 | FUSED RING COMPOUND AND APPLICATION THEREOF | 武汉朗来科技发展有限公司 | 2021-07-08 | — | — | WO | disclosed |