Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12469388 | 0.77 | HTR2B (0.57) | KDM4EHTR2BMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL23624231 | 0.75 | NPC1 (0.41) | KDM4EPDCD1CD274HTR2BTP53 | |
| SCHEMBL24660285 | 0.74 | LMNA (0.39) | KDM4EPDCD1CD274TP53MAPT | |
| SCHEMBL20539648 | 0.73 | HSD17B13 (0.42) | PDCD1CD274S1PR1 | |
| SCHEMBL4034919 | 0.71 | RARA (0.49) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30522700 | 0.71 | PDCD1 (0.35) | KDM4EPDCD1CD274 | |
| SCHEMBL28486432 | 0.71 | PDCD1 (0.35) | KDM4EPDCD1CD274 | |
| SCHEMBL12875931 | 0.70 | ALDH1A1 (0.46) | MAPTALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL18003926 | 0.69 | ALDH1A1 (0.34) | KDM4EPDCD1CD274MAPTALDH1A1 | |
| SCHEMBL23102434 | 0.69 | KDM4E (0.41) | KDM4ETP53MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021136354-A1 | BIPHENYL DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2021-07-08 | — | — | WO | disclosed |