Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GLP1R | P43220 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TARBP2 | Q15633 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24961545 | 0.84 | LMNA (0.56) | LMNATDP1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL30952911 | 0.84 | LMNA (0.56) | LMNATDP1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL24823308 | 0.81 | ALDH1A1 (0.40) | LMNATDP1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL24823387 | 0.77 | NPC1 (0.46) | LMNATDP1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL30311035 | 0.77 | NPC1 (0.46) | LMNATDP1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL30310925 | 0.77 | NPC1 (0.46) | LMNATDP1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL24824154 | 0.77 | NPC1 (0.46) | LMNATDP1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL30310830 | 0.76 | TARBP2 (0.41) | LMNAALDH1A1HPGDL3MBTL1CYP1A2 | |
| SCHEMBL24824174 | 0.76 | TARBP2 (0.41) | LMNAALDH1A1HPGDL3MBTL1CYP1A2 | |
| SCHEMBL24826088 | 0.76 | KDM4E (0.41) | LMNAALDH1A1HPGDGLP1RCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021136244-A1 | TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 中国医药研究开发中心有限公司 | 2021-07-08 | — | — | WO | disclosed |