Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23628496 | 0.82 | L3MBTL1 (0.43) | L3MBTL1CETPADORA1MAPTKDM4E | |
| SCHEMBL15426481 | 0.80 | L3MBTL1 (0.44) | L3MBTL1CETPADORA1MAPTTP53 | |
| SCHEMBL31146057 | 0.80 | L3MBTL1 (0.44) | L3MBTL1CETPADORA1MAPTTP53 | |
| SCHEMBL31145979 | 0.79 | L3MBTL1 (0.43) | L3MBTL1CETPADORA1MAPTTP53 | |
| SCHEMBL23628469 | 0.78 | KDM4E (0.46) | L3MBTL1CETPADORA1MAPTTP53 | |
| SCHEMBL23628488 | 0.73 | CETP (0.50) | L3MBTL1CETPMAPTKDM4ELMNA | |
| SCHEMBL17552177 | 0.73 | MAPT (0.64) | MAPTTP53POLBALDH1A1TSHR | |
| SCHEMBL23628493 | 0.72 | KDM4E (0.46) | L3MBTL1CETPADORA1MAPTTP53 | |
| SCHEMBL23628487 | 0.71 | KDM4E (0.42) | L3MBTL1CETPADORA1MAPTKDM4E | |
| SCHEMBL20715308 | 0.70 | ACHE (0.43) | CETPADORA1MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353178-B1 | BICYCLIC COMPOUNDS AS DUAL ATX/CA INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-07-14 | — | — | EP | claimed |