Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 6/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.55 |
| ▸ | NNMT | P40261 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | GRN | P28799 | 1/20 | 0.45 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL702548 | 0.85 | TAS1R3 (0.63) | GABRA1NNMTTAS1R3TAS1R1GRN | |
| SCHEMBL3436035 | 0.81 | GRN (0.50) | GABRA5GABRA1NNMTTAS1R3TAS1R1 | |
| SCHEMBL20812214 | 0.81 | NNMT (0.60) | GABRA5GABRA1NNMTGRNSORT1 | |
| SCHEMBL13403407 | 0.81 | HDAC6 (0.54) | GABRA5GABRA1NNMTHTTTAS1R3 | |
| SCHEMBL5784282 | 0.78 | NNMT (0.50) | GABRA5GABRA1NNMTNR1I2CYP2C8 | |
| SCHEMBL23628710 | 0.78 | NNMT (0.50) | GABRA5GABRA1NNMTTAS1R3TAS1R1 | |
| SCHEMBL1882423 | 0.76 | NNMT (0.67) | GABRA1NNMTHTTHDAC6 | |
| SCHEMBL24247501 | 0.76 | GABRA1 (0.55) | GABRA5GABRA1TAS1R3TAS1R1 | |
| SCHEMBL14516103 | 0.75 | NNMT (0.64) | GABRA5NNMTHTTHDAC6 | |
| SCHEMBL5784288 | 0.74 | GRN (0.44) | GABRA5GABRA1NNMTNR1I2CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3847154-A1 | CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS | F. Hoffmann-La Roche AG (CH) | 2021-07-14 | — | — | EP | disclosed |