Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | GPR6 | P46095 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17241734 | 0.94 | SYK (0.47) | POLBACP1RAB9AKMT2ACSNK2A1 | |
| SCHEMBL7609220 | 0.79 | RAB9A (0.45) | POLBNPC1RAB9AKMT2AIKBKB | |
| SCHEMBL28962064 | 0.76 | ACP1 (0.54) | ACP1KMT2ATLR7LCK | |
| SCHEMBL7541257 | 0.76 | PTPN1 (0.62) | NPC1RAB9AKMT2AIKBKBPTPN1 | |
| SCHEMBL4484697 | 0.73 | HPGDS (0.54) | POLBNPC1RAB9AKMT2ASYK | |
| SCHEMBL10468175 | 0.73 | ROCK2 (0.48) | KMT2ACSNK2A1CSNK2A2CSNK2BSYK | |
| SCHEMBL27492651 | 0.72 | KDM4E (0.56) | NPC1RAB9A | |
| SCHEMBL11717624 | 0.72 | LCK (0.49) | CSNK2A1CSNK2A2CSNK2BLCK | |
| SCHEMBL8807038 | 0.72 | SMN1; SMN2 (0.56) | NPC1RAB9AKMT2AIKBKBPTPN1 | |
| SCHEMBL10467341 | 0.72 | CSNK2A1 (0.36) | CSNK2A1CSNK2A2CSNK2BSYKMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3846800-A1 | COMPOUNDS FOR THE DEGRADATION OF BRD9 OR MTH1 | C4 Therapeutics, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |