Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 7/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.34 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.34 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 2/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264274 | 0.83 | HSD17B13 (0.37) | IRAK1IRAK4HSD17B13PFKFB3RIPK2 | |
| SCHEMBL2364571 | 0.74 | MET (0.31) | MET | |
| SCHEMBL2364334 | 0.74 | SYK (0.33) | MET | |
| SCHEMBL13449352 | 0.73 | IRAK4 (0.39) | IRAK1IRAK4PFKFB3MET | |
| SCHEMBL12516359 | 0.73 | IRAK4 (0.33) | IRAK1IRAK4HSD17B13MET | |
| SCHEMBL2266777 | 0.72 | MET (0.35) | IRAK1IRAK4HSD17B13METFGFR2 | |
| SCHEMBL12517612 | 0.72 | RXRA (0.35) | IRAK1IRAK4PFKFB3METFGFR1 | |
| SCHEMBL13449395 | 0.72 | IRAK1 (0.33) | IRAK1IRAK4RIPK2MET | |
| SCHEMBL13449355 | 0.72 | HSD17B13 (0.36) | IRAK1IRAK4HSD17B13PFKFB3ELANE | |
| SCHEMBL13449347 | 0.72 | HSD17B13 (0.36) | IRAK1IRAK4HSD17B13ELANEMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |