Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12517939 | 0.86 | ACVR1 (0.33) | SYKACVR1MET | |
| SCHEMBL2364571 | 0.85 | MET (0.31) | MET | |
| SCHEMBL13449344 | 0.78 | FGFR1 (0.31) | MET | |
| SCHEMBL2265089 | 0.76 | ACVR1 (0.33) | SYKACVR1MET | |
| SCHEMBL2364258 | 0.76 | ACVR1 (0.36) | SYKACVR1 | |
| SCHEMBL12517961 | 0.75 | DUT (0.36) | MET | |
| SCHEMBL13449359 | 0.74 | MET (0.32) | MET | |
| SCHEMBL2362950 | 0.74 | IRAK1 (0.34) | MET | |
| SCHEMBL13449380 | 0.73 | MET (0.40) | MET | |
| SCHEMBL12517951 | 0.73 | RXRA (0.34) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |