Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 8/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23270754 | 0.88 | TBXA2R (0.41) | ALOX5APTBXA2RP2RX3PTGESALOX5 | |
| SCHEMBL3090980 | 0.83 | LMNA (0.48) | TBXA2RP2RX3KDM4ECYP1A2CYP3A4 | |
| SCHEMBL3088330 | 0.82 | TP53 (0.46) | CYP1A2CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL3091570 | 0.78 | P2RX3 (0.45) | P2RX3KDM4EMAPTTSHRHSD17B10 | |
| SCHEMBL23270748 | 0.78 | ALOX5AP (0.63) | ALOX5APPTGESALOX5PTGES2KDM4E | |
| SCHEMBL30181768 | 0.78 | ALOX5AP (0.63) | ALOX5APPTGESALOX5PTGES2KDM4E | |
| SCHEMBL3095865 | 0.77 | CCR2 (0.43) | TBXA2RP2RX3CYP1A2CYP3A4MAPT | |
| SCHEMBL3095854 | 0.77 | CCR2 (0.43) | TBXA2RP2RX3CYP1A2CYP3A4MAPT | |
| SCHEMBL9959514 | 0.77 | TP53 (0.44) | KDM4ECYP1A2CYP3A4MAPTCYP2C9 | |
| SCHEMBL3096637 | 0.75 | MAPT (0.52) | P2RX3KDM4ECYP1A2CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043423-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS | SUZHOU MEDNES PHARMA TECH CO., LTD. (CN) | 2024-02-08 | — | — | US | disclosed |
| US-20210214353-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS | SUZHOU MEDNES PHARMA TECH CO., LTD. (CN) | 2021-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240043423-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS | SHH, GLI1, SMO | ALOX5AP 3709/4885TBXA2R 2140/4885P2RX3 3466/4885 |
| US-20210214353-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS | SHH, GLI1, SMO | ALOX5AP 3783/4885TBXA2R 2087/4885P2RX3 4056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.