Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 9/20 | 0.49 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GCGR | P47871 | 2/20 | 0.39 |
| ▸ | GIPR | P48546 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.38 |
| ▸ | RORA | P35398 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MRE11 | P49959 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM4B | O94953 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23631886 | 1.00 | RORC (0.49) | RORCPDE2AKDM4EGCGRGIPR | |
| SCHEMBL28715136 | 0.91 | RORC (0.51) | RORCPDE2AKDM4EGCGRGIPR | |
| SCHEMBL28715139 | 0.91 | RORC (0.51) | RORCPDE2AKDM4EGCGRGIPR | |
| SCHEMBL25136874 | 0.85 | RORC (0.45) | RORCPDE2AGCGRGIPRMRE11 | |
| SCHEMBL23632098 | 0.83 | PDE2A (0.51) | RORCPDE2ARORA | |
| SCHEMBL23632100 | 0.83 | PDE2A (0.51) | RORCPDE2ARORA | |
| SCHEMBL28699837 | 0.82 | RORC (0.49) | RORCKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL28699794 | 0.82 | RORC (0.55) | RORCKDM4ERAB9A | |
| SCHEMBL28699838 | 0.82 | RORC (0.49) | RORCKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL28699796 | 0.82 | RORC (0.55) | RORCKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072542-B | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-114075139-A | Five-membered heteroaromatic ring compound and application thereof in medicines | 广东东阳光药业有限公司 | 2022-02-22 | — | — | CN | disclosed |
| WO-2021139595-A1 | RORγT INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 东莞市东阳光新药研发有限公司 | 2021-07-15 | — | — | WO | disclosed |
| CN-113072542-A | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | disclosed |