Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | EBP | Q15125 | 2/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24951989 | 1.00 | SIGMAR1 (0.44) | SIGMAR1EBPPDK1KDM4EHTT | |
| SCHEMBL23638497 | 1.00 | SIGMAR1 (0.44) | SIGMAR1EBPPDK1KDM4EHTT | |
| SCHEMBL9432796 | 0.78 | SIGMAR1 (0.50) | SIGMAR1EBPPDK1KDM4EHTT | |
| SCHEMBL12059653 | 0.78 | — | — | |
| SCHEMBL7519293 | 0.77 | SIGMAR1 (0.44) | SIGMAR1EBPPDK1KDM4EHTT | |
| SCHEMBL5805370 | 0.77 | SIGMAR1 (0.44) | SIGMAR1EBPPDK1KDM4EHTT | |
| SCHEMBL24951986 | 0.75 | PDK1 (0.41) | PDK1 | |
| SCHEMBL26820367 | 0.75 | PDK1 (0.41) | PDK1 | |
| SCHEMBL24951152 | 0.74 | HRH3 (0.39) | KDM4EALDH1A1LMNA | |
| SCHEMBL6133223 | 0.74 | SIGMAR1 (0.41) | SIGMAR1EBPPDK1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901664-B | Pyridone compounds and uses thereof | 南京再明医药有限公司 | 2024-07-02 | — | — | CN | disclosed |
| EP-4376845-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |
| CN-114901664-A | Pyridone compound and application thereof | 江苏先声药业有限公司 | 2022-08-12 | — | — | CN | disclosed |
| WO-2021139775-A1 | PYRIDONE COMPOUND AND APPLICATION | 江苏先声药业有限公司 | 2021-07-15 | — | — | WO | disclosed |