Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12409052 | 0.82 | HSD11B1 (0.41) | HRH2HRH1HRH3GRIN2DGRIN3B | |
| SCHEMBL18872100 | 0.78 | CYP2D6 (0.37) | HRH2HRH1HRH3GRIN2DGRIN3B | |
| SCHEMBL13656334 | 0.77 | KCNH2 (0.36) | HRH2HRH1HRH3GRIN2DGRIN3B | |
| SCHEMBL24461610 | 0.77 | KDM1A (0.35) | HRH2HRH1HRH3GRIN2DGRIN3B | |
| SCHEMBL16106910 | 0.77 | S1PR1 (0.36) | HRH2HRH1HRH3DRD2S1PR1 | |
| SCHEMBL28096700 | 0.76 | HRH2 (0.32) | HRH2HRH1HRH3GRIN2DGRIN3B | |
| SCHEMBL27655711 | 0.76 | SLC18A3 (0.47) | HRH1 | |
| SCHEMBL4550235 | 0.74 | KDM4E (0.43) | DRD2S1PR1S1PR3S1PR5 | |
| SCHEMBL14968300 | 0.74 | ALDH1A1 (0.41) | MAPTDRD2S1PR1S1PR3S1PR5 | |
| SCHEMBL30901702 | 0.72 | ALOX15 (0.52) | HRH2HRH1HRH3DRD2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848363-B1 | TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND | MEDSHINE DISCOVERY INC (CN) | 2023-07-19 | — | — | EP | disclosed |
| EP-3848363-A1 | TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND | Medshine Discovery Inc. (CN) | 2021-07-14 | — | — | EP | disclosed |