Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.48 |
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | WNT1 | P04628 | 2/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.43 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.43 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18979455 | 0.88 | F10 (0.59) | F10DYRK1AGSK3BWNT1PLOD2 | |
| SCHEMBL18979420 | 0.80 | F10 (0.61) | F10DYRK1AGSK3BWNT1 | |
| SCHEMBL18979422 | 0.77 | F10 (0.62) | F10DYRK1AGSK3BWNT1 | |
| SCHEMBL18979456 | 0.76 | F10 (0.61) | F10DYRK1AGSK3BWNT1 | |
| SCHEMBL19546746 | 0.72 | DYRK1A (0.80) | DYRK1AGSK3BCLK4WNT1 | |
| SCHEMBL23635137 | 0.70 | DYRK1A (0.39) | F10DYRK1AGSK3BWNT1RPS6KA3 | |
| SCHEMBL23916841 | 0.70 | DYRK1A (0.61) | DYRK1AGSK3BWNT1 | |
| SCHEMBL17027847 | 0.70 | ADRA2C (0.56) | RPS6KA3DHFRCHEK1ACHE | |
| SCHEMBL23916557 | 0.69 | DYRK1A (0.59) | DYRK1AGSK3BCLK4WNT1 | |
| SCHEMBL23916701 | 0.69 | DYRK1A (0.58) | DYRK1AGSK3BCLK4WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107909-B1 | ANTIMITOTIC AMIDES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS | FROST BIOLOGIC INC (US) | 2021-07-14 | — | — | EP | disclosed |