Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | AKT2 | P31751 | 1/20 | 0.30 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23635327 | 0.96 | HSD11B1 (0.37) | HSD11B1NR1I2AKT1AKT2AKT3 | |
| SCHEMBL23635369 | 0.92 | NR1I2 (0.35) | HSD11B1NR1I2MMP2MMP9MAPK1 | |
| SCHEMBL23635365 | 0.90 | NR1I2 (0.39) | HSD11B1NR1I2MAPK1ALDH1A1CYP1A2 | |
| SCHEMBL23635370 | 0.90 | HSD11B1 (0.33) | HSD11B1NR1I2MAPK1L3MBTL1MEN1 | |
| SCHEMBL23635328 | 0.90 | HSD11B1 (0.34) | HSD11B1NR1I2MAPK1L3MBTL1MEN1 | |
| SCHEMBL23635346 | 0.88 | HSD11B1 (0.43) | HSD11B1NR1I2MAPK1MEN1ALDH1A1 | |
| SCHEMBL23635284 | 0.86 | HSD11B1 (0.34) | HSD11B1NR1I2AKT1AKT2AKT3 | |
| SCHEMBL23635331 | 0.85 | HSD11B1 (0.42) | HSD11B1NR1I2 | |
| SCHEMBL23635367 | 0.81 | HSD11B1 (0.35) | HSD11B1NR1I2MAPK1L3MBTL1MEN1 | |
| SCHEMBL23635332 | 0.80 | L3MBTL1 (0.35) | HSD11B1AKT1AKT2AKT3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021142420-A1 | PYRAZOLO[1,5-a]PYRIMIDIN-7(4H)-ONE INHIBITORS OF DYNEIN | KAPOOR TARUN M (US) | 2021-07-15 | — | — | WO | disclosed |