Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.31 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23635327 | 0.89 | HSD11B1 (0.37) | HSD11B1ALDH1A1HPGDMAPK1L3MBTL1 | |
| SCHEMBL23635367 | 0.88 | HSD11B1 (0.35) | HSD11B1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL23635283 | 0.86 | HSD11B1 (0.37) | HSD11B1ALDH1A1HPGDMAPK1L3MBTL1 | |
| SCHEMBL23635331 | 0.86 | HSD11B1 (0.42) | HSD11B1NR1I2 | |
| SCHEMBL23635369 | 0.85 | NR1I2 (0.35) | HSD11B1MAPK1L3MBTL1NR1I2 | |
| SCHEMBL23635370 | 0.85 | HSD11B1 (0.33) | HSD11B1ALDH1A1HPGDMAPK1L3MBTL1 | |
| SCHEMBL23635346 | 0.84 | HSD11B1 (0.43) | HSD11B1ALDH1A1MAPK1CYP2C9NR1I2 | |
| SCHEMBL23635332 | 0.84 | L3MBTL1 (0.35) | HSD11B1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL23635365 | 0.84 | NR1I2 (0.39) | HSD11B1ALDH1A1MAPK1CYP2C9NR1I2 | |
| SCHEMBL23635398 | 0.82 | MEN1 (0.36) | HSD11B1KDM4EALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021142420-A1 | PYRAZOLO[1,5-a]PYRIMIDIN-7(4H)-ONE INHIBITORS OF DYNEIN | KAPOOR TARUN M (US) | 2021-07-15 | — | — | WO | disclosed |