Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 12/20 | 0.38 |
| ▸ | AXL | P30530 | 4/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363732 | 1.00 | CRHR1 (0.47) | CRHR1SMYD3MERTKAXLTYRO3 | |
| Hydrochloric Acid SCHEMBL14150158 | 0.98 | CRHR1 (0.47) | CRHR1SMYD3MERTKAXLTYRO3 | |
| Hydrochloric Acid SCHEMBL14150159 | 0.98 | CRHR1 (0.47) | CRHR1SMYD3MERTKAXLTYRO3 | |
| Hydrochloric Acid SCHEMBL2364863 | 0.79 | CRHR1 (0.52) | CRHR1SMYD3 | |
| SCHEMBL27877442 | 0.75 | CRHR1 (0.46) | CRHR1SMYD3ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL27877441 | 0.75 | CRHR1 (0.46) | CRHR1SMYD3ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL2323151 | 0.71 | CRHR1 (0.56) | CRHR1SMYD3L3MBTL1 | |
| SCHEMBL27877443 | 0.71 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL10193114 | 0.69 | CA12 (0.40) | CRHR1 | |
| SCHEMBL6357438 | 0.66 | CA12 (0.35) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102753527-B | Cyclohexyl amide derivatives as crf receptor antagonists | NOVARTIS AG | 2014-12-24 | — | — | CN | disclosed |
| EP-2531490-B1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2014-10-15 | — | — | EP | disclosed |
| US-8835444-B2 | Cyclohexyl amide derivatives as CRF receptor antagonists | NOVARTIS AG (CH) | 2014-09-16 | — | — | US | disclosed |
| US-8835444-B2 | Cyclohexyl amide derivatives as CRF receptor antagonists | NOVARTIS AG (CH) | 2014-09-16 | — | — | US | disclosed |
| US-8835444-B2 | Cyclohexyl amide derivatives as CRF receptor antagonists | NOVARTIS AG (CH) | 2014-09-16 | — | — | US | disclosed |
| US-20120316185-A1 | Cyclohexyl Amide Derivatives as CRF Receptor Antagonists | NOVARTIS AG (CH) | 2012-12-13 | — | — | US | disclosed |
| US-20120316185-A1 | Cyclohexyl Amide Derivatives as CRF Receptor Antagonists | NOVARTIS AG (CH) | 2012-12-13 | — | — | US | disclosed |
| US-20120316185-A1 | Cyclohexyl Amide Derivatives as CRF Receptor Antagonists | NOVARTIS AG (CH) | 2012-12-13 | — | — | US | disclosed |
| EP-2531490-A1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | Novartis AG (CH) | 2012-12-12 | — | — | EP | disclosed |
| CN-102753527-A | Cyclohexyl amide derivatives as crf receptor antagonists | NOVARTIS AG | 2012-10-24 | — | — | CN | disclosed |
| WO-2011095450-A1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2011-08-11 | — | — | WO | disclosed |
| WO-2011095450-A1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2011-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316185-A1 | Cyclohexyl Amide Derivatives as CRF Receptor Antagonists | CRHR2, CRHR1, CRH | CRHR1 2/4885SMYD3 4541/4885MERTK 2947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.