Sugi Predict

Sugi Predict / Compounds / SCHEMBL2363760

SCHEMBL2363760

SCHEMBL2363760

Cc1cnc(Nc2cccc(-c3cnc(N4CCN(C)CC4)o3)n2)s1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KCNH2 Q12809 2/20 0.42
▸ KDR P35968 5/20 0.42
▸ CHEK1 O14757 4/20 0.39
▸ CDK7 P50613 3/20 0.39
▸ FLT3 P36888 3/20 0.37
▸ KIT P10721 2/20 0.37
▸ PIK3CG P48736 1/20 0.36
▸ CCNT1 O60563 1/20 0.35
▸ CDK4 P11802 1/20 0.35
▸ CCND1 P24385 1/20 0.35
▸ CDK9 P50750 1/20 0.35
▸ CDK6 Q00534 1/20 0.35
▸ CDK11A Q9UQ88 1/20 0.35
▸ AURKA O14965 1/20 0.35
▸ CCNK O75909 2/20 0.35
▸ DDB1 Q16531 2/20 0.35
▸ CDK12 Q9NYV4 2/20 0.35
▸ MAP3K12 Q12852 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.34
▸ MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14674242 0.85 RAB9A (0.40) CHEK1CDK7KITKDM4EMEN1
SCHEMBL14673663 0.83 KDR (0.40) KDRCHEK1CDK7CCNT1CDK4
SCHEMBL27899683 0.81 CCNK (0.43) FLT3CDK9CDK6AURKACCNK
SCHEMBL13825903 0.81 KCNH2 (0.43) KCNH2FLT3CDK9CDK6CCNK
SCHEMBL14673902 0.80 JAK2 (0.52) KDRCDK9CDK6CCNKKDM4E
SCHEMBL14673616 0.80 KARS1 (0.52) MAP3K12JAK2
SCHEMBL2364512 0.79 WEE1 (0.42) FLT3AURKAKMT2ASRCJAK2
SCHEMBL14673765 0.78 ABL1 (0.39) FLT3CCNT1CDK4CCND1CDK9
SCHEMBL2225190 0.78 KDR (0.49) KDRCHEK1CDK7CCNKDDB1
SCHEMBL14680969 0.76 TRPV1 (0.42) KCNH2CDK9CDK6CCNKMAP3K12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130035331-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2013-02-07 — — US claimed
CN-102812022-A Thiazole and oxazole kinase inhibitors AB SCIENCE 2012-12-05 — — CN claimed
EP-2523952-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB Science (FR) 2012-11-21 — — EP claimed
WO-2011086085-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2011-07-21 — — WO claimed
EP-2523952-B1 OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2015-03-04 — — EP disclosed
US-8962665-B2 Thiazole and oxazole kinase inhibitors AB SCIENCE (FR) 2015-02-24 — — US disclosed
US-8962665-B2 Thiazole and oxazole kinase inhibitors AB SCIENCE (FR) 2015-02-24 — — US disclosed
US-8962665-B2 Thiazole and oxazole kinase inhibitors AB SCIENCE (FR) 2015-02-24 — — US disclosed
US-20130035331-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2013-02-07 — — US disclosed
US-20130035331-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2013-02-07 — — US disclosed
US-20130035331-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2013-02-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130035331-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS SYK, LTK, MERTK KCNH2 4135/4885KDR 79/4885CHEK1 310/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.