Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.49 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.49 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493880 | 1.00 | TP53 (0.50) | TP53NPC1RAB9ASMN1; SMN2GNAI3 | |
| SCHEMBL3879759 | 0.98 | GNAI3 (0.50) | TP53NPC1RAB9ASMN1; SMN2GNAI3 | |
| SCHEMBL2364796 | 0.88 | GNAI3 (0.58) | TP53NPC1RAB9ASMN1; SMN2GNAI3 | |
| SCHEMBL16405435 | 0.86 | GNAI3 (0.60) | GNAI3GNAO1GNAI1CNR2CNR1 | |
| SCHEMBL16010753 | 0.85 | GNAI3 (0.69) | GNAI3GNAO1GNAI1CNR2CNR1 | |
| SCHEMBL3868277 | 0.85 | GNAI3 (0.69) | GNAI3GNAO1GNAI1CNR2CNR1 | |
| SCHEMBL3974367 | 0.85 | GNAI3 (0.69) | GNAI3GNAO1GNAI1CNR2CNR1 | |
| SCHEMBL28996573 | 0.83 | CA12 (0.46) | TP53NPC1RAB9ASMN1; SMN2GNAI3 | |
| SCHEMBL4591725 | 0.83 | HTT (0.47) | TP53SMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL3871463 | 0.82 | GNAI3 (0.71) | GNAI3GNAO1GNAI1CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533645-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100373-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |