Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2265089 | 0.81 | ACVR1 (0.33) | ACVR1SYKPIM1 | |
| SCHEMBL12517939 | 0.76 | ACVR1 (0.33) | ACVR1SYK | |
| SCHEMBL2364334 | 0.76 | SYK (0.33) | ACVR1SYK | |
| SCHEMBL2365097 | 0.72 | FGFR1 (0.33) | IRAK4 | |
| SCHEMBL13275185 | 0.70 | FGFR1 (0.36) | IRAK4IRAK1 | |
| SCHEMBL13449344 | 0.68 | FGFR1 (0.31) | — | |
| SCHEMBL2222323 | 0.67 | IRAK1 (0.35) | IRAK1CACNA2D1 | |
| SCHEMBL13274835 | 0.67 | MET (0.40) | IRAK4IRAK1 | |
| SCHEMBL2265508 | 0.67 | MET (0.34) | — | |
| SCHEMBL12517961 | 0.66 | DUT (0.36) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | claimed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | claimed |