SCHEMBL23644663

SCHEMBL23644663

COc1cc(F)c([C@@H]2CNC(=O)[C@H]2OC(N)=O)c(F)c1

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 20/20 0.53
FPR1 P21462 18/20 0.53
CYP3A4 P08684 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28993773 0.79 FPR2 (0.55) FPR2FPR1
SCHEMBL22016004 0.79 FPR2 (0.55) FPR2FPR1
SCHEMBL18106453 0.79 FPR2 (0.55) FPR2FPR1
SCHEMBL28993770 0.79 FPR2 (0.55) FPR2FPR1
SCHEMBL29434330 0.79 FPR2 (0.55) FPR2FPR1
SCHEMBL28332794 0.79 FPR2 (0.55) FPR2FPR1
SCHEMBL21995817 0.78 FPR2 (0.51) FPR2FPR1CYP3A4
SCHEMBL22148275 0.78 FPR2 (0.57) FPR2FPR1CYP3A4
SCHEMBL19559452 0.78 FPR2 (0.57) FPR2FPR1CYP3A4
SCHEMBL16785414 0.78 FPR2 (0.57) FPR2FPR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3634958-B1 CYCLOPROPYL UREA FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-07-21 EP disclosed