SCHEMBL22016004

SCHEMBL22016004

COc1cc(F)c(C2CNC(=O)[C@H]2N)c(F)c1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 20/20 0.55
FPR1 P21462 15/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28993773 1.00 FPR2 (0.55) FPR2FPR1
SCHEMBL28993770 1.00 FPR2 (0.55) FPR2FPR1
SCHEMBL29434330 1.00 FPR2 (0.55) FPR2FPR1
SCHEMBL28332794 1.00 FPR2 (0.55) FPR2FPR1
SCHEMBL18106453 1.00 FPR2 (0.55) FPR2FPR1
SCHEMBL18590525 0.83 FPR2 (0.40) FPR2FPR1
SCHEMBL20581283 0.82 FPR2 (0.55) FPR2FPR1
SCHEMBL22015872 0.82 FPR2 (0.61) FPR2FPR1
SCHEMBL20041873 0.82 FPR2 (0.44) FPR2FPR1
SCHEMBL18106704 0.80 FPR2 (0.56) FPR2FPR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230348426-A1 OXOPYRROLIDINE FPR2 AGONISTS BRISTOL MYERS SQUIBB CO (US) 2023-11-02 US disclosed
US-20210395200-A1 SYNTHETIC PROCESSES FOR THE PRODUCTION OF 1-((3S,4R)-4-(2,6-DIFLUORO-4-METHOXYPHENYL)-2-OXOPYRROLIDIN-3-YL)-3-PHENYLUREA BRISTOL MYERS SQUIBB CO (US) 2021-12-23 US disclosed
WO-2020102643-A1 SYNTHETIC PROCESSES FOR THE PRODUCTION OF 1-((3S,4R)-4-(2,6-DIFLUORO-4-METHOXYPHENYL)-2-OXOPYRROLIDIN-3-YL)-3-PHENYLUREA BRISTOL-MYERS SQUIBB COMPANY (US) 2020-05-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210395200-A1 SYNTHETIC PROCESSES FOR THE PRODUCTION OF 1-((3S,4R)-4-(2,6-DIFLUORO-4-METHOXYPHENYL)-2-OXOPYRROLIDIN-3-YL)-3-PHENYLUREA UMPS, ODC1, DDC FPR2 4139/4885FPR1 4407/4885
US-20230348426-A1 OXOPYRROLIDINE FPR2 AGONISTS FPR1, FPR2, FPR3 FPR2 2/4885FPR1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.