Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16825003 | 0.83 | RBP4 (0.35) | GRM5MEN1KMT2ACYP2C9SLC9A1 | |
| SCHEMBL16959916 | 0.82 | OPRL1 (0.40) | PTGDR2OPRL1 | |
| SCHEMBL2338827 | 0.81 | GPR119 (0.52) | DPP4ALDH1A1MAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL27623434 | 0.81 | NPC1 (0.44) | GRM5NPC1PTGDR2OPRL1RAB9A | |
| SCHEMBL14992618 | 0.81 | RBP4 (0.43) | NPC1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL2099816 | 0.80 | RBP4 (0.47) | NPC1PTGDR2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL27642929 | 0.78 | SCD5 (0.44) | GRM5NPC1PTGDR2RAB9ASCD5 | |
| SCHEMBL23034991 | 0.77 | SCD5 (0.60) | GRM5PTGDR2OPRL1SCD5CYP2C9 | |
| SCHEMBL17397790 | 0.77 | NPC1 (0.39) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6810820 | 0.76 | IDO1 (0.45) | NPC1PTGDR2OPRL1RAB9ASCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358675-A1 | 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds | Theravance, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010056941-A1 | 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2010-05-20 | — | — | WO | disclosed |