Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 6/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31069238 | 1.00 | MAPT (0.42) | MAPTPOLBMTNR1AP2RX7LMNA | |
| SCHEMBL23645385 | 1.00 | MAPT (0.42) | MAPTPOLBMTNR1AP2RX7LMNA | |
| SCHEMBL23645566 | 0.86 | TGFBR1 (0.40) | MAPTPOLBP2RX7LMNATRPV1 | |
| SCHEMBL31069256 | 0.86 | TGFBR1 (0.40) | MAPTPOLBP2RX7LMNATRPV1 | |
| SCHEMBL23645565 | 0.86 | TGFBR1 (0.40) | MAPTPOLBP2RX7LMNATRPV1 | |
| SCHEMBL23645315 | 0.73 | NR4A2 (0.40) | MAPTPOLBLMNATP53 | |
| SCHEMBL31069233 | 0.73 | NR4A2 (0.40) | MAPTPOLBLMNATP53 | |
| SCHEMBL21810872 | 0.69 | MAPT (0.43) | MAPTPOLBLMNATP53 | |
| SCHEMBL4508616 | 0.63 | POLB (0.53) | MAPTPOLBMTNR1ALMNAMALT1 | |
| SCHEMBL23652952 | 0.63 | POLB (0.53) | MAPTPOLBMTNR1ALMNAMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12421225-B2 | Heteroaromatic amide derivative and medicament containing the same | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2025-09-23 | — | — | US | disclosed |
| EP-3851436-B1 | NOVEL HETEROAROMATIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME | KAKEN PHARMA CO LTD (JP) | 2024-06-12 | — | — | EP | disclosed |
| US-20230086366-A1 | Novel heteroaromatic amide derivative and medicament containing the same | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2023-03-23 | — | — | US | disclosed |
| EP-3851436-A1 | NOVEL HETEROAROMATIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2021-07-21 | — | — | EP | disclosed |
| CN-112689636-A | Novel heteroatom aromatic amide derivative and drug containing the same | 科研制药株式会社 | 2021-04-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230086366-A1 | Novel heteroaromatic amide derivative and medicament containing the same | SCN7A, HCN4, SCN4A | MAPT 4617/4885POLB 3414/4885MTNR1A 552/4885 |
| US-12421225-B2 | Heteroaromatic amide derivative and medicament containing the same | SCN7A, HCN4, SCN4A | MAPT 4572/4885POLB 3234/4885MTNR1A 475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.