Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | USP1 | O94782 | 1/20 | 0.30 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | LDHB | P07195 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2230884 | 0.87 | JAK2 (0.42) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2233315 | 0.75 | JAK2 (0.52) | JAK2JAK3 | |
| Toluene SCHEMBL2342437 | 0.74 | DYRK1A (0.37) | DYRK1AEPHB3 | |
| SCHEMBL1693166 | 0.72 | USP1 (0.63) | JAK2USP1JAK3 | |
| SCHEMBL2347275 | 0.69 | EPHB3 (0.39) | DYRK1AEPHB3 | |
| SCHEMBL4382927 | 0.68 | P2RX3 (0.49) | PIK3CA | |
| SCHEMBL3962873 | 0.68 | P2RX3 (0.49) | PIK3CA | |
| SCHEMBL2233691 | 0.67 | MAPT (0.36) | DYRK1AEPHB3 | |
| SCHEMBL2230590 | 0.67 | DYRK1A (0.35) | DYRK1AEPHB3 | |
| SCHEMBL2231287 | 0.66 | ACVR2A (0.39) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101161-A1 | PYRAZOLE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-08-25 | — | — | WO | disclosed |