Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.54 |
| ▸ | PSMD14 | O00487 | 5/20 | 0.95 |
| ▸ | COPS5 | Q92905 | 5/20 | 0.95 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MMP2 | P08253 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | MMP8 | P22894 | 1/20 | 0.58 |
| ▸ | CCR1 | P32246 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30079755 | 0.98 | PSMD14 (1.00) | PSMD14COPS5LMNAKDM4EMMP2 | |
| SCHEMBL536578 | 0.98 | PSMD14 (1.00) | PSMD14COPS5LMNAKDM4EMMP2 | |
| SCHEMBL4819240 | 0.95 | PSMD14 (0.95) | PSMD14COPS5LMNAKDM4EMMP2 | |
| SCHEMBL9221538 | 0.95 | PSMD14 (0.95) | PSMD14COPS5LMNAKDM4EMMP2 | |
| SCHEMBL7431585 | 0.95 | PSMD14 (0.95) | PSMD14COPS5LMNAKDM4EMMP2 | |
| Hydrochloric Acid SCHEMBL1333579 | 0.95 | PSMD14 (0.95) | PSMD14COPS5LMNAKDM4EMMP2 | |
| SCHEMBL1822441 | 0.95 | PSMD14 (0.95) | PSMD14COPS5LMNAKDM4EMMP2 | |
| SCHEMBL7333832 | 0.95 | PSMD14 (0.95) | PSMD14COPS5LMNAKDM4EMMP2 | |
| Hydrochloric Acid SCHEMBL30430691 | 0.95 | PSMD14 (0.95) | PSMD14COPS5LMNAKDM4EMMP2 | |
| SCHEMBL27629030 | 0.95 | PSMD14 (0.95) | PSMD14COPS5LMNAKDM4EMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230076415-A1 | METHODS AND COMPOSITIONS FOR TREATING MELANOMA | UNIVERSITE COTE D'AZUR - GRAND CHÂTEAU (FR) | 2023-03-09 | — | — | US | disclosed |
| EP-4090770-A1 | METHODS AND COMPOSITIONS FOR TREATING MELANOMA | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2022-11-23 | — | — | EP | disclosed |
| WO-2021144426-A1 | METHODS AND COMPOSITIONS FOR TREATING MELANOMA | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2021-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230076415-A1 | METHODS AND COMPOSITIONS FOR TREATING MELANOMA | PSMD14, PSMB4, PSMD4 | CHRM1 4868/4885PSMD14 1/4885COPS5 1770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.