Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL195968 | 0.88 | POLQ (0.45) | POLQNPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL194877 | 0.87 | LMNA (0.41) | POLQPPARGALDH1A1TDP1L3MBTL1 | |
| SCHEMBL5331837 | 0.78 | LMNA (0.42) | POLQALDH1A1TDP1L3MBTL1KCNN4 | |
| SCHEMBL2096212 | 0.77 | POLQ (0.44) | POLQNPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2583273 | 0.76 | POLQ (0.47) | POLQNPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29278841 | 0.76 | ALDH1A1 (0.40) | POLQNPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL236492 | 0.76 | ALDH1A1 (0.46) | ALDH1A1TDP1L3MBTL1GAAPOLB | |
| SCHEMBL3793278 | 0.75 | POLQ (0.40) | POLQNPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6037560 | 0.74 | ALDH1A1 (0.39) | POLQNPSR1ALDH1A1TDP1ATM | |
| SCHEMBL28361227 | 0.74 | SLC6A2 (0.53) | POLQSLC6A2SLC6A4SLC6A3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401276-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2012-01-04 | — | — | EP | disclosed |