Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | EED | O75530 | 1/20 | 0.45 |
| ▸ | LPO | P22079 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1618174 | 0.78 | FUCA1 (0.50) | SIGMAR1ALDH1A1DRD2DRD3 | |
| SCHEMBL2330991 | 0.78 | ADRB1 (0.55) | KDM4EALDH1A1DRD2MAPTMEN1 | |
| SCHEMBL2921693 | 0.77 | SIGMAR1 (0.63) | SIGMAR1KDM4EALDH1A1GAACMA1 | |
| SCHEMBL2918653 | 0.77 | SIGMAR1 (0.63) | SIGMAR1KDM4EALDH1A1GAACMA1 | |
| Hydrochloric Acid SCHEMBL1619305 | 0.77 | FUCA1 (0.49) | SIGMAR1ALDH1A1DRD2DRD3 | |
| SCHEMBL2910904 | 0.76 | SIGMAR1 (0.57) | SIGMAR1KDM4EALDH1A1GAACMA1 | |
| SCHEMBL28186295 | 0.75 | SIGMAR1 (0.90) | SIGMAR1KDM4EALDH1A1GAALMNA | |
| SCHEMBL20804357 | 0.75 | SIGMAR1 (0.90) | SIGMAR1KDM4EALDH1A1GAALMNA | |
| SCHEMBL3847058 | 0.75 | SIGMAR1 (0.72) | SIGMAR1KDM4EALDH1A1GAADRD2 | |
| SCHEMBL29463795 | 0.75 | SIGMAR1 (0.72) | SIGMAR1KDM4EALDH1A1GAADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356125-A1 | DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | Targacept, Inc. (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010002971-A1 | DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2010-01-07 | — | — | WO | disclosed |