Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 11/20 | 0.75 |
| ▸ | NR3C1 | P04150 | 10/20 | 0.75 |
| ▸ | AR | P10275 | 8/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | SHBG | P04278 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20048417 | 0.87 | NR3C1 (0.81) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL20048212 | 0.86 | NR3C1 (1.00) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL30324808 | 0.86 | NR3C1 (1.00) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL20048227 | 0.86 | NR3C1 (1.00) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL20048415 | 0.85 | NR3C1 (0.87) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL8541045 | 0.83 | PGR (0.59) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL20048414 | 0.83 | PGR (0.62) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL23645233 | 0.83 | PGR (0.62) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL20048250 | 0.83 | PGR (0.62) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL9019768 | 0.80 | PGR (0.68) | PGRNR3C1ARCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3851444-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | Oric Pharmaceuticals, Inc. (US) | 2021-07-21 | — | — | EP | disclosed |