Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IAPP | P10997 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16048607 | 0.85 | CYP4F2 (0.46) | ALDH1A1HPGDHSD17B10FFAR4 | |
| SCHEMBL28358420 | 0.80 | PPARA (0.44) | ALDH1A1HPGDHSD17B10FFAR4FFAR1 | |
| SCHEMBL28453244 | 0.78 | PPARA (0.44) | IAPPTAAR1PPARAALOX5OR51E2 | |
| SCHEMBL28358438 | 0.75 | GPR52 (0.39) | ALDH1A1HPGDHSD17B10FFAR4FFAR1 | |
| SCHEMBL28389058 | 0.73 | IAPP (0.43) | ALDH1A1IAPPALOX5OR51E2 | |
| SCHEMBL16048571 | 0.71 | CYP4F2 (0.45) | ALDH1A1HPGDFFAR4 | |
| SCHEMBL28801709 | 0.71 | ALOX5 (0.40) | ALDH1A1IAPPTAAR1ALOX5OR51E2 | |
| SCHEMBL13545173 | 0.70 | MTNR1A (0.55) | IAPPTAAR1 | |
| SCHEMBL28612635 | 0.69 | IAPP (0.49) | IAPPALOX5OR51E2 | |
| SCHEMBL16048995 | 0.69 | CYP4F2 (0.48) | ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409671-B1 | ISOTHIAZOLE DERIVATIVES AS GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2021-07-21 | — | — | EP | disclosed |