Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | ESR1 | P03372 | 6/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.37 |
| ▸ | AKT1 | P31749 | 7/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374388 | 0.81 | PDK1 (0.46) | ESR1ESR2 | |
| SCHEMBL1903425 | 0.78 | HTR2A (0.39) | HTR2AAKT1AKT2SMN1; SMN2HTR2C | |
| SCHEMBL1094982 | 0.77 | HTR2A (0.42) | HTR2AESR1ESR2AKT1AKT2 | |
| SCHEMBL1903827 | 0.76 | ESR2 (0.58) | ESR1ESR2 | |
| SCHEMBL1904807 | 0.73 | ESR1 (0.50) | ESR1ESR2 | |
| SCHEMBL6631121 | 0.67 | ESR1 (0.41) | ESR1ESR2MTNR1B | |
| SCHEMBL6631057 | 0.67 | HTR2A (0.45) | HTR2AESR1ESR2MTNR1BHTR2C | |
| SCHEMBL15849169 | 0.66 | ESR1 (0.47) | ESR1ESR2MTNR1B | |
| SCHEMBL6635416 | 0.66 | MTNR1B (0.38) | HTR2AESR1ESR2SMN1; SMN2MTNR1B | |
| SCHEMBL30878560 | 0.64 | ESR1 (0.53) | HTR2AESR1ESR2SMN1; SMN2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2363394-A1 | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its salts, solvates or hydrates and its use for the treatment of CNS disorders | Arena Pharmaceuticals, Inc. (US) | 2011-09-07 | — | — | EP | disclosed |
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |