Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1903827 | 0.80 | ESR2 (0.58) | ESR1ESR2CA1CA2 | |
| SCHEMBL15828368 | 0.78 | ESR1 (0.55) | ESR1ESR2CA12CA1CA2 | |
| SCHEMBL1904807 | 0.74 | ESR1 (0.50) | ESR1ESR2 | |
| SCHEMBL15849166 | 0.72 | ESR1 (0.41) | ESR1ESR2MTNR1BCA12CA1 | |
| SCHEMBL1095978 | 0.72 | ESR1 (0.42) | ESR1ESR2MAOA | |
| SCHEMBL6631359 | 0.70 | KMT2A (0.42) | MTNR1BALDH1A1 | |
| SCHEMBL15849139 | 0.70 | ESR1 (0.37) | ESR1ESR2MTNR1BCA12CA1 | |
| SCHEMBL6635416 | 0.69 | MTNR1B (0.38) | ESR1ESR2MTNR1B | |
| SCHEMBL2374388 | 0.69 | PDK1 (0.46) | ESR1ESR2 | |
| SCHEMBL25722288 | 0.68 | SMN1; SMN2 (0.58) | MTNR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |