SCHEMBL23657366

SCHEMBL23657366

NS(=O)(=O)c1ccc(NCCCC2CCNCC2)cc1

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 1/20 0.45
ITGA2B P08514 1/20 0.45
CA2 P00918 15/20 0.44
CA1 P00915 14/20 0.44
CA9 Q16790 10/20 0.43
CA12 O43570 8/20 0.43
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
THRB P10828 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14621353 0.83 NMT1 (0.43) ITGB3ITGA2B
SCHEMBL3389631 0.78 ALDH1A1 (0.52) ITGB3ITGA2BMAPT
SCHEMBL14621446 0.78 KHK (0.41) ITGB3ITGA2B
SCHEMBL23657189 0.76 CA1 (0.63) CA2CA1CA9CA12
SCHEMBL17315368 0.73 CA1 (0.68) CA2CA1CA9CA12
SCHEMBL27917814 0.72 GBA1 (0.56) CA2CA1CA9CA12MAPT
SCHEMBL14621354 0.72 ITGB3 (0.40) ITGB3ITGA2B
SCHEMBL18361697 0.71 CA2 (0.49) CA2CA1CA9CA12
SCHEMBL25031242 0.71 CA2 (0.68) CA2CA1CA9CA12MAPT
SCHEMBL28736087 0.71 CA2 (0.54) CA2CA1CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021145729-A1 NOVEL COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION (KR) 2021-07-22 WO disclosed