Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.46 |
| ▸ | HTR2B | P41595 | 8/20 | 0.46 |
| ▸ | HTR2A | P28223 | 7/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 2/20 | 0.32 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6653629 | 0.85 | ADRA2A (0.35) | HTR2CHTR2BHTR2A | |
| SCHEMBL6532681 | 0.84 | HTR2C (0.49) | HTR2CHTR2BHTR2ADRD1DRD5 | |
| SCHEMBL22609757 | 0.74 | HTR2C (0.60) | HTR2CHTR2BHTR2ADRD1DRD5 | |
| SCHEMBL1105041 | 0.71 | HTR2C (0.60) | HTR2CHTR2BHTR2ADRD1DRD5 | |
| SCHEMBL2365641 | 0.70 | HTR2A (0.43) | HTR2CHTR2BHTR2ADRD1DRD5 | |
| SCHEMBL14483788 | 0.69 | HTR2C (0.44) | HTR2CHTR2BHTR2ADRD1DRD5 | |
| SCHEMBL3847064 | 0.69 | HTR2C (0.44) | HTR2CHTR2BHTR2ADRD1DRD5 | |
| SCHEMBL2365900 | 0.68 | HTR2A (0.51) | HTR2CHTR2A | |
| SCHEMBL6631310 | 0.68 | FGFR4 (0.35) | HTR2CHTR2BHTR2AABHD6 | |
| SCHEMBL2365770 | 0.67 | TNFRSF1A (0.37) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2363394-A1 | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its salts, solvates or hydrates and its use for the treatment of CNS disorders | Arena Pharmaceuticals, Inc. (US) | 2011-09-07 | — | — | EP | disclosed |