Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.32 |
| ▸ | HTR2B | P41595 | 4/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2365801 | 0.85 | HTR2C (0.46) | HTR2CHTR2BHTR2A | |
| SCHEMBL2365775 | 0.76 | PTPN1 (0.33) | PTPN1 | |
| SCHEMBL2365632 | 0.74 | ADRA2A (0.37) | ADRA2AADRA2BADRA2C | |
| SCHEMBL1907864 | 0.74 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CHTR2CHTR2A | |
| SCHEMBL1903335 | 0.72 | PTPN1 (0.35) | PTPN1 | |
| SCHEMBL6532681 | 0.70 | HTR2C (0.49) | HTR2CHTR2BHTR2A | |
| SCHEMBL2365900 | 0.69 | HTR2A (0.51) | PTPN1HTR2CHTR2A | |
| SCHEMBL1901752 | 0.66 | HTR2C (0.69) | ADRA2AADRA2BADRA2CPTPN1HTR2C | |
| SCHEMBL1095399 | 0.66 | HTR2C (0.69) | ADRA2AADRA2BADRA2CPTPN1HTR2C | |
| SCHEMBL1095400 | 0.66 | HTR2C (0.69) | ADRA2AADRA2BADRA2CPTPN1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |