Sugi Predict

Sugi Predict / Compounds / SCHEMBL2365993

SCHEMBL2365993

SCHEMBL2365993

Cc1cc(C2CC2)cnc1N1CCN(C(=O)c2ccc(N3CC(C)(C)OC3=O)cc2F)CC1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ GRM5 P41594 2/20 0.38
▸ HTT P42858 2/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ SSTR5 P35346 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ TP53 P04637 2/20 0.35
▸ TOP2B Q02880 1/20 0.35
▸ DGAT1 O75907 1/20 0.34
▸ TSHR P16473 2/20 0.34
▸ MAPT P10636 2/20 0.34
▸ POLB P06746 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ EGLN1 Q9GZT9 1/20 0.33
▸ SLC6A9 P48067 1/20 0.33
▸ SLC6A5 Q9Y345 1/20 0.33
▸ LMNA P02545 2/20 0.33
▸ CPS1 P31327 2/20 0.33
▸ GBA1 P04062 1/20 0.33
▸ CALML3 P27482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2366736 0.89 GRM5 (0.40) GRM5HTTKMT2ASSTR5KDM4E
SCHEMBL2366241 0.88 SSTR5 (0.43) GRM5HTTKMT2ASSTR5KDM4E
SCHEMBL2365868 0.87 GRM5 (0.41) GRM5HTTSSTR5KDM4EDGAT1
SCHEMBL2366094 0.87 TP53 (0.35) SSTR5TP53DGAT1MAPTLMNA
SCHEMBL2366987 0.86 SSTR5 (0.39) GRM5HTTKMT2ASSTR5KDM4E
SCHEMBL12240539 0.86 HTT (0.40) HTTKMT2AKDM4ETP53TOP2B
SCHEMBL2366591 0.86 SSTR5 (0.34) SSTR5TP53DGAT1MAPTLMNA
Hydrochloric Acid SCHEMBL2365824 0.85 HTT (0.39) HTTKMT2AKDM4ETP53TOP2B
SCHEMBL2366088 0.85 SSTR5 (0.33) SSTR5KDM4ETP53DGAT1MAPT
SCHEMBL14688134 0.84 HTT (0.39) HTTKMT2AKDM4ETP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2364975-B1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORP (JP) 2013-06-12 — — EP disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 — — US disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 — — US disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 — — US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 — — US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 — — US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 — — US disclosed
EP-2364975-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE Mitsubishi Tanabe Pharma Corporation (JP) 2011-09-14 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MMP9, MMP10, MMP2 GRM5 4644/4885HTT 1580/4885KMT2A 800/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.