Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | CASP7 | P55210 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15258013 | 0.98 | HTT (0.59) | HTTSMN1; SMN2PIM1TDP1NPC1 | |
| SCHEMBL12411727 | 0.95 | SMN1; SMN2 (0.55) | HTTSMN1; SMN2PIM1TDP1NPC1 | |
| SCHEMBL18590412 | 0.86 | KDM4E (0.61) | HTTSMN1; SMN2PIM1NPC1ALDH1A1 | |
| SCHEMBL23666441 | 0.84 | CSNK1E (0.52) | HTTSMN1; SMN2TDP1ALDH1A1HSD17B10 | |
| SCHEMBL22083655 | 0.79 | HTT (0.55) | HTTSMN1; SMN2PIM1TDP1NPC1 | |
| SCHEMBL24074245 | 0.79 | HTT (0.51) | HTTSMN1; SMN2PIM1TDP1NPC1 | |
| SCHEMBL22083693 | 0.78 | HTT (0.51) | HTTSMN1; SMN2PIM1TDP1NPC1 | |
| SCHEMBL21765939 | 0.78 | PDE10A (0.44) | HTTSMN1; SMN2PIM1KDM4EDYRK3 | |
| SCHEMBL18590994 | 0.78 | RXFP1 (0.46) | HTTSMN1; SMN2PIM1NPC1RAB9A | |
| SCHEMBL31381255 | 0.78 | HTT (0.48) | HTTSMN1; SMN2NPSR1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210221817-A1 | NOVEL HETEROAROMATIC COMPOUNDS AS POTENT MODULATORS OF THE HIPPO-YAP SIGNALING PATHWAY LATS1/2 KINASES | Nivien Therapeutics Compny (US) | 2021-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210221817-A1 | NOVEL HETEROAROMATIC COMPOUNDS AS POTENT MODULATORS OF THE HIPPO-YAP SIGNALING PATHWAY LATS1/2 KINASES | LATS1, LATS2, YAP1 | HTT 3021/4885SMN1; SMN2 4201/4885PIM1 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.