Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BPTF | Q12830 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15258013 | 0.86 | HTT (0.59) | HTTSMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL12411727 | 0.86 | SMN1; SMN2 (0.55) | HTTSMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL23666402 | 0.84 | HTT (0.58) | IRAK4HTTSMN1; SMN2KDM4EMAPT | |
| SCHEMBL18590412 | 0.83 | KDM4E (0.61) | HTTSMN1; SMN2KDM4EMAPTCYP1A2 | |
| SCHEMBL15254681 | 0.82 | CSNK1E (0.46) | CSNK1EIRAK4HTTSMN1; SMN2BPTF | |
| Hydrochloric Acid SCHEMBL15254596 | 0.81 | CSNK1E (0.45) | CSNK1EIRAK4HTTSMN1; SMN2BPTF | |
| SCHEMBL15272443 | 0.77 | DYRK1A (0.53) | CSNK1EPLD1DYRK3CCNT1CDK9 | |
| SCHEMBL21434305 | 0.77 | SMN1; SMN2 (0.74) | CSNK1EHTTSMN1; SMN2BPTFKDM4E | |
| SCHEMBL21765939 | 0.75 | PDE10A (0.44) | IRAK4HTTSMN1; SMN2KDM4EDYRK3 | |
| SCHEMBL18590994 | 0.75 | RXFP1 (0.46) | HTTSMN1; SMN2KDM4EMAPTDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210221817-A1 | NOVEL HETEROAROMATIC COMPOUNDS AS POTENT MODULATORS OF THE HIPPO-YAP SIGNALING PATHWAY LATS1/2 KINASES | Nivien Therapeutics Compny (US) | 2021-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210221817-A1 | NOVEL HETEROAROMATIC COMPOUNDS AS POTENT MODULATORS OF THE HIPPO-YAP SIGNALING PATHWAY LATS1/2 KINASES | LATS1, LATS2, YAP1 | CSNK1E 93/4885IRAK4 2630/4885HTT 3021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.