SCHEMBL23679161

SCHEMBL23679161

N#Cc1ccc(-c2ccc3c4ccc(-c5ccc(C#N)cc5C#N)cc4n(-c4ccc(-c5nc(-c6ccccc6)nc(-c6ccccc6)n5)c(-c5ccc(C(F)(F)F)cc5C(F)(F)F)c4)c3c2)c(C#N)c1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
XDH P47989 2/20 0.35
ALOX5AP P20292 1/20 0.35
FEN1 P39748 1/20 0.35
ABCG2 Q9UNQ0 1/20 0.33
PDPK1 O15530 1/20 0.33
AR P10275 5/20 0.32
TRPA1 O75762 1/20 0.32
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
HPGD P15428 1/20 0.31
MAPK1 P28482 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MAT2A P31153 1/20 0.31
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31
GRIN1 Q05586 1/20 0.31
GRIN2B Q13224 1/20 0.31
PGR P06401 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23679113 0.98 XDH (0.34) XDHALOX5APFEN1ABCG2PDPK1
SCHEMBL23543448 0.93 AR (0.40) ABCG2PDPK1ARTRPA1ALDH1A1
SCHEMBL23679130 0.92 MAT2A (0.34) ABCG2PDPK1ALDH1A1LMNAMAT2A
SCHEMBL23543319 0.92 XDH (0.37) XDHALOX5APFEN1PDPK1ALDH1A1
SCHEMBL23679107 0.91 PTPN5 (0.37) ABCG2PDPK1TRPA1ALDH1A1LMNA
SCHEMBL23543520 0.90 AR (0.38) ABCG2PDPK1ARTRPA1PGR
SCHEMBL20834375 0.90 XDH (0.42) XDHALOX5APFEN1ABCG2PDPK1
SCHEMBL23679110 0.89 PDPK1 (0.36) ABCG2PDPK1MAT2AGRIN1GRIN2B
SCHEMBL23543395 0.89 XDH (0.35) XDHALOX5APFEN1ABCG2PDPK1
SCHEMBL23679172 0.89 XDH (0.36) XDHALOX5APFEN1ABCG2PDPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3673031-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2021-07-28 EP disclosed