SCHEMBL23679130

SCHEMBL23679130

N#Cc1ccc2c3ccc(C#N)cc3n(-c3ccc(-c4nc(-c5ccccc5)nc(-c5ccccc5)n4)c(-c4ccc(C(F)(F)F)cc4C(F)(F)F)c3)c2c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAT2A P31153 2/20 0.34
PDPK1 O15530 1/20 0.34
USP1 O94782 1/20 0.33
WDR48 Q8TAF3 1/20 0.33
ABCG2 Q9UNQ0 3/20 0.32
ABCB1 P08183 2/20 0.32
KCNH2 Q12809 2/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2B Q13224 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.32
ACP1 P24666 1/20 0.32
DGAT1 O75907 1/20 0.31
SOAT1 P35610 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23679107 0.93 PTPN5 (0.37) MAT2APDPK1ABCG2GRIN1GRIN2B
SCHEMBL23679131 0.93 MAT2A (0.33) MAT2APDPK1USP1WDR48ABCG2
SCHEMBL23679161 0.92 XDH (0.35) MAT2APDPK1ABCG2GRIN1GRIN2B
SCHEMBL23679134 0.92 USP1 (0.33) MAT2APDPK1USP1WDR48ABCG2
SCHEMBL23543314 0.92 USP1 (0.40) PDPK1USP1WDR48ABCG2ABCB1
SCHEMBL23679110 0.91 PDPK1 (0.36) MAT2APDPK1USP1WDR48ABCG2
SCHEMBL23679109 0.91 CYP1A2 (0.36) MAT2APDPK1ABCG2GRIN1GRIN2B
SCHEMBL23679049 0.90 MAT2A (0.40) MAT2AABCG2KCNH2LMNACYP1A2
SCHEMBL23543347 0.90 KIF11 (0.38) MAT2APDPK1ABCG2ABCB1KCNH2
SCHEMBL23543430 0.89 GRIN1 (0.38) PDPK1ABCG2GRIN1GRIN2BPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3673031-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2021-07-28 EP disclosed