Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.39 |
| ▸ | BCL2 | P10415 | 6/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369044 | 0.88 | MCL1 (0.34) | MCL1BCL2KITKDRTEK | |
| SCHEMBL2368964 | 0.83 | MAPT (0.34) | KDRMEN1KMT2A | |
| SCHEMBL5791364 | 0.78 | PTGS1 (0.43) | MCL1BCL2KITKDRTEK | |
| SCHEMBL3386423 | 0.76 | MCL1 (0.41) | MCL1BCL2KITKDRTEK | |
| SCHEMBL3386427 | 0.74 | SMN1; SMN2 (0.61) | MCL1BCL2BCL2L1MEN1KMT2A | |
| SCHEMBL2368440 | 0.73 | MCL1 (0.48) | MCL1BCL2KITKDRTEK | |
| SCHEMBL5792044 | 0.67 | TDP1 (0.42) | MCL1BCL2KITKDRTEK | |
| SCHEMBL2368665 | 0.65 | LMNA (0.50) | MEN1KMT2A | |
| SCHEMBL3384503 | 0.65 | MCL1 (0.36) | MCL1BCL2KITKDRTEK | |
| SCHEMBL2369084 | 0.64 | HTT (0.56) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |