Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 12/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368435 | 0.88 | MCL1 (0.39) | MCL1BCL2KDRKITTEK | |
| SCHEMBL5792044 | 0.80 | TDP1 (0.42) | MCL1BCL2TDP1KDRKIT | |
| SCHEMBL3384503 | 0.77 | MCL1 (0.36) | MCL1BCL2TDP1KDRKIT | |
| SCHEMBL3384508 | 0.76 | SMN1; SMN2 (0.58) | MCL1BCL2TDP1KDRALDH1A1 | |
| SCHEMBL2369264 | 0.68 | ADORA1 (0.37) | MCL1TDP1ALDH1A1CYP2C19CLK4 | |
| SCHEMBL6358968 | 0.67 | ADORA1 (0.34) | TMIGD3ADORA1 | |
| SCHEMBL5791364 | 0.67 | PTGS1 (0.43) | MCL1BCL2KDRKITTEK | |
| SCHEMBL3386423 | 0.65 | MCL1 (0.41) | MCL1BCL2KDRKITTEK | |
| SCHEMBL3386427 | 0.63 | SMN1; SMN2 (0.61) | MCL1BCL2TDP1ALDH1A1CYP2C19 | |
| SCHEMBL2369084 | 0.62 | HTT (0.56) | ALDH1A1MEN1KMT2ALMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |