Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5790688 | 0.79 | ADORA1 (0.50) | LMNAKMT2AALDH1A1MAPK1HSD17B10 | |
| SCHEMBL2369094 | 0.78 | LMNA (0.45) | LMNAKMT2AALDH1A1MAPK1HSD17B10 | |
| SCHEMBL3385355 | 0.76 | ALDH1A1 (0.45) | LMNAKMT2AALDH1A1MAPK1HSD17B10 | |
| SCHEMBL3385359 | 0.75 | LMNA (0.52) | LMNAKMT2AALDH1A1MAPK1HSD17B10 | |
| SCHEMBL2369123 | 0.74 | ALDH1A1 (0.55) | LMNAKMT2AALDH1A1MAPK1HSD17B10 | |
| SCHEMBL6358973 | 0.71 | LMNA (0.55) | LMNAALDH1A1MAPK1HSD17B10ALOX15 | |
| SCHEMBL2368674 | 0.68 | ALDH1A1 (0.54) | LMNAKMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL2369084 | 0.68 | HTT (0.56) | LMNAKMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3383431 | 0.67 | ALDH1A1 (0.44) | LMNAALDH1A1MAPK1HSD17B10ALOX15 | |
| SCHEMBL2368935 | 0.66 | ALDH1A1 (0.44) | LMNAALDH1A1MAPK1HSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |