Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DTYMK | P23919 | 1/20 | 0.51 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.49 |
| ▸ | HNF4A | P41235 | 2/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | EIF4E | P06730 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27985266 | 0.92 | DTYMK (0.58) | DTYMKACMSDHNF4ADHFRMCL1 | |
| SCHEMBL25302339 | 0.86 | ABCB1 (0.52) | DTYMKACMSDHNF4ADHFRMCL1 | |
| SCHEMBL31232900 | 0.81 | CRHBP (0.46) | DTYMKACMSDHNF4ADHFRMCL1 | |
| Acetamide SCHEMBL20185440 | 0.81 | TSHR (0.62) | DTYMKTSHR | |
| SCHEMBL27908400 | 0.80 | CRHBP (0.51) | DTYMKACMSDHNF4ADHFRMCL1 | |
| SCHEMBL5384165 | 0.80 | DTYMK (0.55) | DTYMKTSHREIF4E | |
| SCHEMBL8372988 | 0.80 | CRHBP (0.51) | DTYMKACMSDHNF4ADHFRMCL1 | |
| SCHEMBL5193454 | 0.80 | CRHBP (0.59) | DTYMKACMSDHNF4ADHFRMCL1 | |
| SCHEMBL8372989 | 0.78 | CRHBP (0.53) | DTYMKACMSDHNF4ADHFRMCL1 | |
| SCHEMBL14283133 | 0.77 | ABCB1 (0.58) | ACMSDHNF4ACRHBPCRHR2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367940-B1 | Mutant penicillin G acylases | DSM SINOCHEM PHARM NL BV (NL) | 2017-11-22 | — | — | EP | disclosed |
| US-8541199-B2 | Mutant penicillin G acylases | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2013-09-24 | — | — | US | disclosed |
| US-20110256585-A1 | MUTANT PENICILLIN G ACYLASES | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2011-10-20 | — | — | US | disclosed |
| EP-2367940-A2 | MUTANT PENICILLIN G ACYLASES | DSM IP Assets B.V. (NL) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010072765-A2 | MUTANT PENICILLIN G ACYLASES | DSM IP ASSETS B.V. (NL) | 2010-07-01 | — | — | WO | disclosed |