Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 | P33527 | 1/20 | 0.67 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.66 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.66 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.66 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10747448 | 0.91 | ABCC1 (0.67) | ABCC1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL23686117 | 0.90 | LMNA (0.64) | ABCC1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL23686104 | 0.88 | KDM4E (0.69) | ABCC1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL23686115 | 0.88 | CACNA1F (0.66) | ABCC1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL23686116 | 0.88 | KMT2A (0.70) | CACNA1FCACNA1DCACNA1SCACNA1CCYP3A4 | |
| SCHEMBL9217355 | 0.86 | HPGD (0.66) | ABCC1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL23668762 | 0.86 | LMNA (0.59) | ABCC1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL6946916 | 0.85 | CYP2C9 (0.56) | ABCC1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL21001936 | 0.85 | LMNA (0.58) | ABCC1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL23686216 | 0.84 | MEN1 (0.78) | CACNA1FCACNA1DCACNA1SCACNA1CCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210230117-A1 | DIHYDROPYRIDINES FOR THE TREATMENT OF COGNITIVE IMPAIRMENT OR TRAUMATIC BRAIN INJURY | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2021-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230117-A1 | DIHYDROPYRIDINES FOR THE TREATMENT OF COGNITIVE IMPAIRMENT OR TRAUMATIC BRAIN INJURY | GAP43, SYNJ1, PSD | ABCC1 2418/4885CACNA1F 272/4885CACNA1D 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.