Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 9/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | GFER | P55789 | 3/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23686350 | 0.97 | RAB9A (0.59) | RAB9ANPC1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL23686359 | 0.92 | RAB9A (0.52) | RAB9ANPC1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL23686351 | 0.87 | KCNH2 (0.64) | RAB9ANPC1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1821159 | 0.76 | RAB9A (1.00) | RAB9ANPC1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL21895103 | 0.75 | KMT2A (0.52) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4488019 | 0.74 | MEN1 (0.48) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL15147259 | 0.73 | KCNH2 (0.53) | RAB9ANPC1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9380274 | 0.70 | KMT2A (0.87) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL259707 | 0.70 | RAB9A (0.69) | RAB9ANPC1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL19500906 | 0.68 | RAB9A (0.64) | RAB9ANPC1LMNASMN1; SMN2CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230034584-A1 | INHIBITORS OF SHP2 | BAYER AKTIENGESELLSCHAFT (DE) | 2023-02-02 | — | — | US | disclosed |
| US-20210230300-A1 | INHIBITORS OF SHP2 | BAYER AKTIENGESELLSCHAFT (DE) | 2021-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230300-A1 | INHIBITORS OF SHP2 | PTPN1, PTPN2, PTPRJ | RAB9A 1569/4885NPC1 2793/4885LMNA 4827/4885 |
| US-20230034584-A1 | INHIBITORS OF SHP2 | PTPN1, PTPN2, PTPRJ | RAB9A 1569/4885NPC1 2793/4885LMNA 4827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.