Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23686350 | 0.92 | RAB9A (0.59) | RAB9ANPC1KCNH2MEN1KMT2A | |
| SCHEMBL23686232 | 0.92 | RAB9A (0.61) | RAB9ANPC1KCNH2MEN1KMT2A | |
| SCHEMBL23686351 | 0.86 | KCNH2 (0.64) | RAB9ANPC1KCNH2MEN1KMT2A | |
| SCHEMBL21895103 | 0.71 | KMT2A (0.52) | KCNH2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL14349548 | 0.69 | RAB9A (0.54) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL1821159 | 0.69 | RAB9A (1.00) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL4155889 | 0.67 | NPC1 (0.52) | RAB9ANPC1MEN1KMT2ACXCR3 | |
| SCHEMBL22305935 | 0.66 | AR (0.60) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL10076588 | 0.66 | RECQL (0.68) | RAB9ANPC1MAPTALDH1A1LMNA | |
| SCHEMBL3615155 | 0.66 | ALOX5 (0.51) | RAB9ANPC1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230034584-A1 | INHIBITORS OF SHP2 | BAYER AKTIENGESELLSCHAFT (DE) | 2023-02-02 | — | — | US | disclosed |
| US-20210230300-A1 | INHIBITORS OF SHP2 | BAYER AKTIENGESELLSCHAFT (DE) | 2021-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230300-A1 | INHIBITORS OF SHP2 | PTPN1, PTPN2, PTPRJ | RAB9A 1569/4885NPC1 2793/4885KCNH2 4257/4885 |
| US-20230034584-A1 | INHIBITORS OF SHP2 | PTPN1, PTPN2, PTPRJ | RAB9A 1569/4885NPC1 2793/4885KCNH2 4257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.