Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 5/20 | 0.54 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.54 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23686108 | 0.87 | HTT (0.50) | LMNAMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23686117 | 0.86 | LMNA (0.64) | LMNAMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23686115 | 0.84 | CACNA1F (0.66) | LMNAMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23686191 | 0.84 | ABCC1 (0.67) | LMNAMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23686104 | 0.84 | KDM4E (0.69) | LMNAMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23686116 | 0.84 | KMT2A (0.70) | LMNAMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23668762 | 0.82 | LMNA (0.59) | LMNAMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL21001936 | 0.81 | LMNA (0.58) | LMNAMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23686114 | 0.80 | LMNA (0.57) | LMNAMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23686216 | 0.80 | MEN1 (0.78) | LMNAMEN1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210230117-A1 | DIHYDROPYRIDINES FOR THE TREATMENT OF COGNITIVE IMPAIRMENT OR TRAUMATIC BRAIN INJURY | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2021-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230117-A1 | DIHYDROPYRIDINES FOR THE TREATMENT OF COGNITIVE IMPAIRMENT OR TRAUMATIC BRAIN INJURY | GAP43, SYNJ1, PSD | LMNA 4376/4885MEN1 3171/4885CYP1A2 4652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.