Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1294 | 0.90 | MEN1 (0.34) | MAPTNPC1NPSR1ALDH1A1KDM4E | |
| SCHEMBL1736 | 0.81 | NR1H4 (0.35) | NR1H4PTGS1MAPTTRPA1ALDH1A1 | |
| SCHEMBL7197 | 0.79 | TBXAS1 (0.39) | NR1H4MAPTTRPA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4758 | 0.74 | IP6K1 (0.40) | NR1H4NPC1TRPA1SMN1; SMN2 | |
| SCHEMBL3368 | 0.73 | IP6K1 (0.39) | TRPA1SMN1; SMN2 | |
| SCHEMBL2369 | 0.72 | CYP1A2 (0.35) | MAPTNPC1NPSR1ALDH1A1KDM4E | |
| SCHEMBL8250811 | 0.69 | PTPN1 (0.36) | NR1H4PTGS1MAPTNPC1NPSR1 | |
| SCHEMBL1563 | 0.69 | PTPN1 (0.47) | PTGS1MAPTNPC1ALDH1A1KDM4E | |
| SCHEMBL8243211 | 0.66 | ALDH1A1 (0.64) | MAPTNPC1NPSR1ALDH1A1KDM4E | |
| SCHEMBL6560 | 0.66 | MAPT (0.50) | MAPTNPC1TRPA1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| EP-2483253-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041729-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |